NCBO ONTOLOGY RECOMMENDER 2.0: AN ENHANCED APPROACH FOR BIOMEDICAL ONTOLOGY RECOMMENDATION



Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia

Summary: Monoallelic inactivation of CCCTC-binding factor (CTCF) in human cancer drives altered methylated genomic states, altered CTCF occupancy at promoter and enhancer regions, Knife Sharpener and deregulated global gene expression.In patients with T cell acute lymphoblastic leukemia (T-ALL), we find that acquired monoallelic CTCF-inactivating e

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Welfare, macroeconomic and trade effects of the hypothetical Southern African Customs Union-United States free trade agreement

Background: There is lingering uncertainty surrounding the renewal of the African Growth and Opportunity Act (AGOA), a United States (US) Trade Act enacted in 2000 and set to expire in 2025.However, the US is a traditional trading partner of the Southern African Customs Union (SACU), and all SACU members predominantly access the US market through A

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SARS-CoV-2 Gamma and Delta Variants of Concern Might Undermine Neutralizing Activity Generated in Response to BNT162b2 mRNA Vaccination

The Delta variant raised concern regarding its ability to evade SARS-CoV-2 vaccines.We evaluated a serum neutralizing response of 172 Italian healthcare workers, three months after complete Comirnaty (BNT162b2 mRNA, BioNTech-copyright) vaccination, testing their sera against viral isolates of Alpha, Gamma and Delta variants, including 36 subjects w

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